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On July 17, 2002, something (referred to as a plague) simultaneously kills every mammal possessing a Y chromosome - including embryos, fertilized eggs, and even sperm. The only exceptions appear to be Yorick Brown, a young amateur escape artist, and his Capuchin monkey Ampersand. Society is plunged into chaos as infrastructures collapse and the surviving women everywhere try to cope with the loss of the men,their survivors' guilt, and the knowledge that humanity is doomed to extinction. Vaughan meticulously crafts the new society that emerges out ofthis chaos, from the conversion of the phallic Washington Monument into a monument to the dead men, to the genesis of the fanatical ultra-feministDaughters of the Amazon, who believe that Mother Earth cleansed itself of the "aberration" of the Y chromosome, to male impersonators becomingvalued romantically and professionally.